We get things done.

We can help you with a single experiment, or take your entire program to IND. We have proven process that streamlines your next milestone.

We can take your drug from discovery through IND approval.

Plug into our intellectual power, expert methodologies, and vast network of resources. We have the right framework and a lean virtual model, to move you forward.

Why we are different.

Our lean, virtual model delivers unlimited bandwidth with maximum customization for our customers’ unique drug development projects, and overcomes delays in study start times, which are common with other, larger, fully integrated competitors. With over 150 years of combined work experience, the Radyus team is standing by to help you navigate forward.

STRATEGIC PLANNING
  • Due diligence
  • Gap analysis
  • Use of proceeds
  • Developmental plans
  • Indication selection
  • Modality selection
  • Protocol development
CONTRACT RESEARCH
  • Unlimited bandwidth
  • No delays
  • Large network of specialized labs in the US and Europe
PROJECT MANAGEMENT
  • FTE model
  • Preclinical study management
  • Extension of R&D team
  • We own the milestones to IND

How we do it.

These five components are the backbone:

  • The cleanroom --a perfected and proprietary ecosystem for growing plants with precision, scale, and with minimum variance.
  • The operating system --an intelligent OS where all the elements are optimized and controlled.
  • The data points----a massive set of data points are generated for research validation and IP.
  • The seeds ---a collaborator's idea that holds the promise,  mixed in with the genetic makeup to make each medicine.
  • The team --our expert hydroponic processing technicians ensure precision and optimization.

Why we do it.

We are transforming the status quo so more medicine can be grown, shared, and produced using molecular pharming. If we can help decentralize drug discovery and production globally for healing and human health, can you imagine the benefits?

The steep prices of biologic drugs are alarming to many patients, physicians, and researchers. It's a bitter pill to swallow for the world when two billion people don't have access to medicine.

In every corner of the world, we envision a Zea Lighthouse that provides a center of excellence for growing therapeutics in plants.

Who we do it for.

For universities, researchers, scientists, and corporations, they get a platform that:

  1. Stabilizes plant growth for the first-time ever
  2. Delivers precision through minimal variation in trial replication batches
  3. Unlocks a depth of rich data collection
  4. Helps validate future research and discovery
  5. Unlocks years of research

For big pharma, they gets access to a novel drug discovery platform that:

  1. Enables much lower drug development costs
  2. Increases development speed
  3. Unlocks a vast selection of target biologics

Experimental Methodologies

From medicinal chemistry to in vivo studies, we provide a wide range of preclinical services by partnering with specialized labs in the US and Europe.

Bioanalytics

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  • High throughput sequencing
  • Single cell sequencing
  • Single crystal structural analysis
  • Nuclear magnetic resonance
  • Liquid chromatography-mass spec
  • Gas chromatography-mass spec
  • High-performance liquid chromatography
  • Inductively coupled plasma optical emission spectrometry
  • MALDI Matrix chromatography

Imaging

We do imaging at Radyus.

  • Live cell imaging
  • Multispectral fluorescence animal imaging
  • Total internal reflection fluorescence
  • Confocal microscopy
  • Cyclotron/ radiochemistry
  • Magnetic resonance imaging
  • Positive emission tomography
  • Computerized tomography
  • Conventional transmission and scanning electron microscopy
  • Cryo-high resolution SEM
  • Cryo-tomography
  • Field emission transmission electron microscopy

Cell & gene-therapies

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  • Gene editing/ CRISPR
  • Gene targeting
  • Transgenic animals
  • Embryonic stem cells
  • Induced pluripotent stem cells
  • Cell isolation and characterization
  • Cell therapy optimization
  • Transduction and transfection optimization

Biomarkers

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  • Flow cytometry
  • Genomics and epigenetics
  • Proteomics
  • Lipodomics and secretomics
  • Glycomics
  • Metabolomics
  • V-Plex and U-Plex immunoassays
  • SNP microarrays
  • lmmunohistochemistry

Antibodies & Biologics

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  • Monoclonal and polyclonal antibodies production
  • Analytical testing and characterization
  • Peptide production and purification
  • Phage, bacterial and yeast displays
  • Cell line development
  • Culture optimization
  • Fermentation: bacterial yeast/mycelial/ plant cell

Animal models

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  • Transgenic animals
  • Select oncology models: bladder, pancreatic, AML & MDS, melanoma, other
  • NHP models: HIV/SIV, RSV, flu, malaria, obesity, metabolic syndrome, Type 1 & 2 diabetes, immunity models
  • Cystic fibrosis
  • Kidney failure
  • Rodent behavioral models: pain, depression and anxiety
  • Alzheimer’s disease
  • Veterinary medicine, small and large animal models

Therapeutic Areas

IMMUNOLOGY

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  • Cytokine, chemokine profiling
  • Immune cell phenotyping
  • Biomarkers
  • lmmunoassays
  • Human TCR repertoire sequencing
  • lmmunohistochemistry and histopathology
  • Transgenic animal models
  • CRISPR gene editing
  • Antibody characterization and development
  • NHP immunity models
  • Microbiome
  • Vaccines

INFECTIOUS DISEASES

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  • BSL3 facilities
  • Pathogen profiling
  • Microbiome
  • Gnotobiotic animal models
  • HIV/SIV non-human primate (NHP) model
  • RSV and flu NHP models
  • Malaria NHP model
  • Cystic fibrosis rodent models
  • RNA viruses models and methods
  • Veterinary medicine, small and large animal models

METABOLIC DISEASES

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  • Metabolomics
  • Glycomics
  • Lipidomics
  • Proteomics
  • Type I and 2 diabetes NHP model
  • Metabolic syndrome NHP model
  • Obesity NHP model
  • Cardio-pulmonary rodent and NHP models
  • Kidney failure small animal models
  • Liver ischemia-reperfusion small animal models

NEUROSCIENCES

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  • Neurosurgical services
  • lntraparenchymal and intrathecal delivery
  • Viral vector drug delivery
  • Brain and spinal cord harvesting
  • Alzheimer's disease models
  • In vitro and in vivo automated intracellular and extracellular recordings
  • Cell culture and brain histology
  • Rodent behavioral models: pain, depression and anxiety

ONCOLOGY

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  • Cell lines and tumor tissue repository
  • Syngeneic, transgenic, xenograft and PDX mouse models
  • Efficacy studies as single agent or in combination
  • Non-GLP toxicology and PK/PD studies (mice, rats, dogss, NHP)
  • In vivo optical bioluminescent and fluorescent imaging
  • Surgical cranial window placement
  • Complete necropsy and tissue collection
  • Histopathology and biochemical analysis

RESPIRATORY

We do respiratory services.

  • COPD animal models
  • Asthma animal models
  • Pulmonary fibrosis animal (IPF) models
  • Aging model of lung fibrosis
  • Acute respiratory syndrome models
  • Interstitial lung disease (ILD) models
  • In vitro lung models
  • iPSC and ex vivo organ-on-a chip models